Causes of Hepatomegaly & Splenomegaly

CAUSES OF HEPATOMEGALY HEPATOMEGALY Massive: ♦        Metastases ♦        Alcoholic liver disease with fatty infiltration ♦        Myeloproliferative disease ♦        Right heart failure ♦        Hepatocellular cancer Moderate: ♦        Haemochromatosis ♦        Haematological disease – e.g. chronic leukaemia, lymphoma, myeloproliferative disorders ♦        Fatty liver – e.g. secondary to diabetes mellitus ♦        Infiltration – e.g. amyloid Mild: ♦        Hepatitis ♦       …

Renin-Angiotensin-Aldosterone system (RAAS)

The renin-angiotensin-aldosterone system (RAAS) plays an important role in regulating blood volume and systemic vascular resistance, which together influence cardiac output and arterial pressure. As the name implies, there are three important components to this system: 1) renin, 2) angiotensin, and 3) aldosterone. Renin, which is primarily released by the kidneys, stimulates the formation of…

Hyperaldosteronism in Cirrhosis

Cirrhosis is a chronic liver disease that is the result of damage to liver tissue with scarring of the liver (fibrosis – nodular regeneration) causing progressive decrease in liver function, excessive fluid in the abdomen (ascites), bleeding disorders (coagulopathy), increased pressure in the blood vessels (portal hypertension), and brain function disorders (hepatic encephalopathy). Excessive alcohol…